capacity of heat in Biology 101: Why should you care?

Laws of thermodynamics experimental laws - they are some of the world was not the first principles are derived: they do thousands and thousands of experiments was derived, and then come up with some of the relationships that can explain all those little test .

In this case we want to keep in touch relationships that thermodynamic quantities (ΔG, ΔH, ΔS, ΔCp) practical and strategic information about biomolecules - 
 

Thermodynamics of the Earth, we started trying to define the same set of "rules biothermodynamics" are their own. No one has anything that could actually called "law" yet, but some very interesting "instructions" there, and one of the strongest in the heat capacity (ΔCp).
It is known that ΔCp quite strongly to changes in exposed surface during the reaction is related to the land. In other words: if two proteins interact and buried surface in some areas of mutual interface - you big heat capacity change (large ΔCp) see. 

 When a protein against a random coil structure in your good books, visit it again buries many levels that random coil was placed inside the protein eaten now tucked - and again: large heat capacity has changed. But here is the exciting part: ΔCp measured for many types of reactions directly to the ground level of a small amount that can be buried or exposed to suit.

capacity of heat video

This means that if you are studying two related proteins that form dimer, and dimer formation ΔCp measure you, then you can direct most of the area (usually in square angstroms) of the interface interaction between two proteins calculated. No crystal structure of the company - are getting very detailed structural information (protein size protein interface in square angstroms) to directly measure a thermodynamic quantity (ΔCp) and, as mentioned in the image, change the sign of the capacity provides thermal information: ΔCp show buried negative levels while positively ΔCp shows the level of exposure (eg, if the reaction goes in the opposite direction, they have positive values ΔCp). [Note: This explains a little bit of oversimplification of the exact relationship between the surface and heat capacity changes, but PR is correct.]

And why things like laws of thermodynamics because the work: many, many laboratory measurements on both sides of the equation (the heat capacity and towards the interaction region) and found that works with almost all the time - for some Types of biological reactions - working together for virtually all of the proteins and protein-protein interactions, it only works for about half of the protein DNA interaction. This is still a very active research area, the feeling is: It works well for many reactions from the ground, maybe a few more aspects of communication we need to discover where you would be a law "is of biothermodynamics ".

capacity of heat video-2

After installing "heat capacity in Biology 101" to describe how to identify and measure ΔCp for molecular biological reactions.